Sequence Detail

ID/Version

Q06986 (UniProt | EBI)

Last sequence update: 2004-04-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase SIAH2; EC=2.3.2.27 {ECO:0000269|PubMed:26070566};AltName: Full=RING-type E3 ubiquitin transferase SIAH2 {ECO:0000305};AltName: Full=Seven in absentia homolog 2; Short=Siah-2; Short=mSiah2;

Provider

SWISS-PROT

Sequence

Polypeptide 325 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Siah2	siah E3 ubiquitin protein ligase 2	53	103	3	12

Sequence references in MGI

J:12699 Della NG, et al., Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). Development. 1993 Apr;117(4):1333-43
J:23010 Della NG, et al., Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis. Cell Tissue Res. 1995 Feb;279(2):411-9
J:86820 Frew IJ, et al., Generation and analysis of Siah2 mutant mice. Mol Cell Biol. 2003 Dec;23(24):9150-61
J:126183 Frew IJ, et al., Normal p53 function in primary cells deficient for Siah genes. Mol Cell Biol. 2002 Dec;22(23):8155-64
J:224604 Huang J, et al., Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015 Jul 31;290(31):19044-54
J:232292 Scortegagna M, et al., Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May;10(5):e1004348
J:266461 DeBruyne JP, et al., Ubiquitin ligase Siah2 regulates RevErbalpha degradation and the mammalian circadian clock. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12420-5