Sequence Detail

ID/Version

Q06180 Q3V259 Q922E7 (UniProt | EBI)

Last sequence update: 2005-01-04
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Tyrosine-protein phosphatase non-receptor type 2; Short=Protein-tyrosine phosphatase PTP-2; EC=3.1.3.48;AltName: Full=MPTP;

Provider

SWISS-PROT

Sequence

Polypeptide 406 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptpn2	protein tyrosine phosphatase, non-receptor type 2	80	103	4	42

Sequence references in MGI

J:1925 Mosinger B Jr, et al., Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):499-503
J:3913 Miyasaka H, et al., Molecular cloning, nucleotide sequence and expression of a cDNA encoding an intracellular protein tyrosine phosphatase, PTPase-2, from mouse testis and T-cells. Mol Cell Biochem. 1992 Dec 2;118(1):91-8
J:42595 You-Ten KE, et al., Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med. 1997 Aug 29;186(5):683-93
J:88185 Persson C, et al., Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol. 2004 Mar;24(5):2190-201
J:90541 Heinonen KM, et al., T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood. 2004 May 1;103(9):3457-64
J:96360 van Vliet C, et al., Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat Immunol. 2005 Mar;6(3):253-60
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:109622 Simoncic PD, et al., T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol. 2006 Jun;26(11):4149-60
J:115366 Simoncic PD, et al., The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol. 2002 Mar 19;12(6):446-53
J:169644 Fukushima A, et al., T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. Diabetes. 2010 Aug;59(8):1906-14
J:181775 Loh K, et al., T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice. Diabetologia. 2012 Feb;55(2):468-78
J:184426 Wiede F, et al., T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J Clin Invest. 2011 Dec;121(12):4758-74
J:197516 Lu X, et al., T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. Mol Cell Biol. 2007 Mar;27(6):2166-79
J:197518 ten Hoeve J, et al., Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol. 2002 Aug;22(16):5662-8
J:197519 Aoki N, et al., A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol. 2002 Jan;16(1):58-69
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89