Sequence Detail

ID/Version

Q05921 Q9ERU7 (UniProt | EBI)

Last sequence update: 2002-02-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=2-5A-dependent ribonuclease; Short=2-5A-dependent RNase; EC=3.1.26.-;AltName: Full=Ribonuclease 4;AltName: Full=Ribonuclease L; Short=RNase L;

Provider

SWISS-PROT

Sequence

Polypeptide 735 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rnasel	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	42	98	2	7

Sequence references in MGI

J:43378 Zhou A, et al., Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell. 1993 Mar 12;72(5):753-65
J:65429 Zhou A, et al., Analysis and origins of the human and mouse RNase L genes: mediators of interferon action (Yr. 2001 Vol. 12 Pg. 878). Mamm Genome. 2000 Nov;11(11):989-92
J:213377 Sorgeloos F, et al., Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L. PLoS Pathog. 2013;9(6):e1003474
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89