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Sequence Detail
ID/Version
Q05512 Q6PDR4 Q8BR95 Q3T9L3 (UniProt | EBI) Last sequence update: 2007-01-23
Last annotation update: 2020-04-22
Sequence
description
from provider
RecName: Full=Serine/threonine-protein kinase MARK2; EC=2.7.11.1; EC=2.7.11.26;AltName: Full=ELKL motif kinase 1; Short=EMK-1;AltName: Full=MAP/microtubule affinity-regulating kinase 2;AltName: Full=PAR1 homolog;AltName: Full=PAR1
Provider SWISS-PROT
Sequence
Polypeptide 776 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Mark2 MAP/microtubule affinity regulating kinase 2 54 74 9 135
Sequence references in MGI J:12907 Inglis JD, et al., Emk, a protein kinase with homologs in yeast maps to mouse chromosome 19. Mamm Genome. 1993;4(7):401-3
J:57958 Bessone S, et al., EMK protein kinase-null mice: dwarfism and hypofertility associated with alterations in the somatotrope and prolactin pathways. Dev Biol. 1999 Oct 1;214(1):87-101
J:68830 Hurov JB, et al., Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. Mol Cell Biol. 2001 May;21(9):3206-19
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120128 Hurov JB, et al., Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5680-5
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory