Sequence Detail

ID/Version

Q04887 Q99KQ0 Q91ZK2 Q8C7L2 (UniProt | EBI)

Last sequence update: 2004-05-10
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Transcription factor SOX-9 {ECO:0000305}; Short=mSox9 {ECO:0000303|PubMed:26527273};

Provider

SWISS-PROT

Sequence

Polypeptide 507 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sox9	SRY (sex determining region Y)-box 9	287	574	4	43

Sequence references in MGI

J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
J:22300 Wright E, et al., The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat Genet. 1995 Jan;9(1):15-20
J:38926 Ng LJ, et al., SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol. 1997 Mar 1;183(1):108-21
J:69875 Bi W, et al., Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6698-703
J:75041 Bi W, et al., Sox9 is required for cartilage formation. Nat Genet. 1999 May;22(1):85-9
J:75124 Kist R, et al., Conditional inactivation of Sox9: a mouse model for campomelic dysplasia. Genesis. 2002 Feb;32(2):121-3
J:79879 Akiyama H, et al., The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28
J:90567 Akiyama H, et al., Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev. 2004 May 1;18(9):1072-87
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102495 Akiyama H, et al., Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70
J:133946 Hargus G, et al., Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitro. Int J Dev Biol. 2008;52(4):323-32
J:168845 Reginensi A, et al., SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet. 2011 Mar 15;20(6):1143-53
J:171508 Ikegami D, et al., Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
J:175121 Huang W, et al., Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol. 2000 Jun;20(11):4149-58
J:175171 Sumi E, et al., SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells. Am J Pathol. 2007 Jun;170(6):1854-64
J:175328 Takigawa Y, et al., The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. J Cell Sci. 2010 Nov 1;123(Pt 21):3780-8
J:183084 Dy P, et al., Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell. 2012 Mar 13;22(3):597-609
J:184685 Wilson CH, et al., Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31(11):2486-97
J:202984 Rockich BE, et al., Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4456-64
J:233055 Liu CF, et al., The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. Nucleic Acids Res. 2015 Sep 30;43(17):8183-203
J:243374 Egunsola AT, et al., Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia. J Clin Invest. 2017 Apr 03;127(4):1475-1484
J:262053 Tan Z, et al., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. PLoS Genet. 2018 Apr;14(4):e1007346
J:264111 Liu CF, et al., SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis. Development. 2018 Jul 18;145(14):dev164459
J:277803 Lui JC, et al., Persistent Sox9 expression in hypertrophic chondrocytes suppresses transdifferentiation into osteoblasts. Bone. 2019 Aug;125:169-177
J:287044 Ikeda T, et al., The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum. 2004 Nov;50(11):3561-73
J:287055 Ohba S, et al., Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte. Cell Rep. 2015 Jul 14;12(2):229-43
J:287059 Zuo C, et al., SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity. Bone Res. 2018;6:12
J:287060 van Gastel N, et al., Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature. 2020 Mar;579(7797):111-117
J:287729 Oh CD, et al., SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters. PLoS One. 2014;9(9):e107577