Sequence Detail

ID/Version

Q04592 E9QPB7 Q62040 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Proprotein convertase subtilisin/kexin type 5; EC=3.4.21.-;AltName: Full=Proprotein convertase 5; Short=PC5;AltName: Full=Proprotein convertase 6; Short=PC6;AltName: Full=Subtilisin-like proprotein convertase 6;

Provider

SWISS-PROT

Sequence

Polypeptide 1877 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pcsk5	proprotein convertase subtilisin/kexin type 5	59	108	4	14

Sequence references in MGI

J:13205 Lusson J, et al., cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6691-5
J:27309 Nakagawa T, et al., Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease. FEBS Lett. 1993 Jul 26;327(2):165-71
J:27310 Nakagawa T, et al., Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4. J Biochem. 1993 Feb;113(2):132-5
J:34068 Constam DB, et al., SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996 Jul;134(1):181-91
J:37018 De Bie I, et al., The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. J Cell Biol. 1996 Dec;135(5):1261-75
J:42730 Rancourt SL, et al., Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation. Dev Genet. 1997;21(1):75-81