Sequence Detail

ID/Version

Q04207 Q62025 (UniProt | EBI)

Last sequence update: 1993-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription factor p65;AltName: Full=Nuclear factor NF-kappa-B p65 subunit;AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;

Provider

SWISS-PROT

Sequence

Polypeptide 549 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	315	147	3	28

Sequence references in MGI

J:35636 Nolan GP, et al., DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell. 1991 Mar 8;64(5):961-9
J:36279 Deloukas P, et al., Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing. Hum Mol Genet. 1993 Nov;2(11):1895-900
J:36469 Linker RA, et al., Cloning of the murine relA (p65 NF-kappa B) gene and comparison to the human gene reveals a distinct first intron. Gene. 1996 Oct 17;176(1-2):119-24
J:53039 Spencer E, et al., Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. Genes Dev. 1999 Feb 1;13(3):284-94
J:75807 Fiorini E, et al., Peptide-induced negative selection of thymocytes activates transcription of an NF-kappaB inhibitor. Mol Cell. 2002 Mar;9(3):637-48
J:84916 Duran A, et al., Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. EMBO J. 2003 Aug 1;22(15):3910-8
J:105108 Covic M, et al., Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J. 2005 Jan 12;24(1):85-96
J:140561 Fukushima H, et al., The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. Mol Cell Biol. 2008 Oct;28(20):6402-12
J:170429 Levy D, et al., Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. Nat Immunol. 2011 Jan;12(1):29-36
J:179897 Sen N, et al., Hydrogen Sulfide-Linked Sulfhydration of NF-kappaB Mediates Its Antiapoptotic Actions. Mol Cell. 2012 Jan 13;45(1):13-24
J:189804 Spengler ML, et al., Core circadian protein CLOCK is a positive regulator of NF-kappaB-mediated transcription. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2457-65
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:204781 Jang EJ, et al., Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet. J Immunol. 2013 Jun 1;190(11):5764-70
J:214847 Stilling RM, et al., K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. EMBO J. 2014 Sep 1;33(17):1912-27
J:244578 Badran YR, et al., Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03;214(7):1937-1947
J:272425 Ramos Pittol JM, et al., Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors. PLoS Biol. 2018 May;16(5):e2004526
J:274548 Shin C, et al., MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kappaB and negatively regulates inflammatory responses. Sci Rep. 2017 Apr 5;7:46097
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306582 Stender JD, et al., Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell. 2012 Oct 12;48(1):28-38