Sequence Detail

ID/Version

Q03963 Q61742 Q62026 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Interferon-induced, double-stranded RNA-activated protein kinase; EC=2.7.11.1;AltName: Full=Eukaryotic translation initiation factor 2-alpha kinase 2; Short=eIF-2A protein kinase 2;AltName: Full=Interferon-inducible RNA-depen

Provider

SWISS-PROT

Sequence

Polypeptide 515 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	65	102	3	15

Sequence references in MGI

J:20201 Tanaka H, et al., Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7995-9
J:23306 Tanaka H, et al., Sequence of the murine interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones. Gene. 1995 Feb 14;153(2):283-4
J:34580 Feng GS, et al., Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5447-51
J:43390 Icely PL, et al., TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem. 1991 Aug 25;266(24):16073-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:167126 Harashima A, et al., Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense. Genes Dev. 2010 Dec 1;24(23):2640-53
J:186690 Lu B, et al., Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 30;488(7413):670-4
J:187314 Irving AT, et al., Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity. 2012 May 25;36(5):795-806
J:192911 Carvalho-Filho MA, et al., Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology. 2012 Nov;153(11):5261-74
J:194275 Stern E, et al., Blocking the eIF2alpha kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory. J Neurosci. 2013 Feb 6;33(6):2517-25
J:196116 Pang Q, et al., Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR. J Biol Chem. 2003 Oct 24;278(43):41709-17
J:196269 Minor RA, et al., Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection. J Interferon Cytokine Res. 2010 Apr;30(4):263-72
J:196300 Liu X, et al., PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells. Blood. 2013 Apr 25;121(17):3364-74
J:198044 He Y, et al., The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. Eur J Immunol. 2013 Apr;43(5):1147-52
J:243779 Nakayama Y, et al., Role of PKR and Type I IFNs in viral control during primary and secondary infection. PLoS Pathog. 2010 Jun 24;6(6):e1000966
J:244722 Thakur SA, et al., Protein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infection. Clin Vaccine Immunol. 2011 Dec;18(12):2060-6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89