Sequence Detail

ID/Version

Q03717 Q8K0D1 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Potassium voltage-gated channel subfamily B member 1 {ECO:0000250|UniProtKB:Q14721};AltName: Full=Voltage-gated potassium channel subunit Kv2.1;AltName: Full=mShab {ECO:0000303|PubMed:2002364};

Provider

SWISS-PROT

Sequence

Polypeptide 857 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	91	102	3	12

Sequence references in MGI

J:11030 Pak MD, et al., A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties. J Neurosci. 1991 Mar;11(3):869-80
J:59765 Xu H, et al., Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit. Circ Res. 1999 Oct 1;85(7):623-33
J:63866 Peretz A, et al., Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J. 2000 Aug 1;19(15):4036-45
J:87608 Kodirov SA, et al., Attenuation of I(K,slow1) and I(K,slow2) in Kv1/Kv2DN mice prolongs APD and QT intervals but does not suppress spontaneous or inducible arrhythmias. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H368-74
J:129963 Jacobson DA, et al., Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell Metab. 2007 Sep;6(3):229-35
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:200490 Peltola MA, et al., AMIGO is an auxiliary subunit of the Kv2.1 potassium channel. EMBO Rep. 2011 Dec;12(12):1293-9
J:220501 Speca DJ, et al., Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Genes Brain Behav. 2014 Apr;13(4):394-408
J:244135 Li XN, et al., The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. J Pharmacol Exp Ther. 2013 Feb;344(2):407-16
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89