Sequence Detail

ID/Version

Q03526 (UniProt | EBI)

Last sequence update: 1995-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein kinase ITK/TSK; EC=2.7.10.2;AltName: Full=IL-2-inducible T-cell kinase;AltName: Full=Kinase EMT;AltName: Full=Kinase TLK;AltName: Full=T-cell-specific kinase;

Provider

SWISS-PROT

Sequence

Polypeptide 625 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itk	IL2 inducible T cell kinase	48	96	3	15

Sequence references in MGI

J:3391 Siliciano JD, et al., itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11194-8
J:3730 Heyeck SD, et al., Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):669-73
J:20701 Yamada N, et al., Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem Biophys Res Commun. 1993 Apr 15;192(1):231-40
J:31230 Liao XC, et al., Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity. 1995 Dec;3(6):757-69
J:54449 Schaeffer EM, et al., Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science. 1999 Apr 23;284(5414):638-41
J:113409 Broussard C, et al., Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity. 2006 Jul;25(1):93-104
J:151074 Fu G, et al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol. 2009 Aug;10(8):848-56
J:159872 Min L, et al., Disrupting the intermolecular self-association of Itk enhances T cell signaling. J Immunol. 2010 Apr 15;184(8):4228-35
J:167539 Qi Q, et al., Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell. J Biol Chem. 2011 Jan 7;286(1):138-46
J:196163 Malhotra N, et al., A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013 Apr 18;38(4):681-93
J:245321 Hwang ES, et al., T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005 Jan 21;307(5708):430-3