Sequence Detail

ID/Version

Q02858 (UniProt | EBI)

Last sequence update: 1995-02-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Angiopoietin-1 receptor; EC=2.7.10.1;AltName: Full=Endothelial tyrosine kinase;AltName: Full=HYK;AltName: Full=STK1;AltName: Full=Tunica interna endothelial cell kinase;AltName: Full=Tyrosine kinase with Ig and EGF homology domains-2

Provider

SWISS-PROT

Sequence

Polypeptide 1122 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tek	TEK receptor tyrosine kinase	97	167	3	22

Sequence references in MGI

J:1682 Dumont DJ, et al., tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene. 1992 Aug;7(8):1471-80
J:3580 Horita K, et al., A novel tyrosine kinase, hyk, expressed in murine embryonic stem cells. Biochem Biophys Res Commun. 1992 Dec 30;189(3):1747-53
J:4692 Dumont DJ, et al., The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors. Oncogene. 1993 May;8(5):1293-301
J:14345 Iwama A, et al., Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells. Biochem Biophys Res Commun. 1993 Aug 31;195(1):301-9
J:15180 Sato TN, et al., Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system [published erratum appears in Proc Natl Acad Sci U S A 1993 Dec 15;90(24):12056]. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9355-8
J:15711 Schnurch H, et al., Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage. Development. 1993 Nov;119(3):957-68
J:20015 Dumont DJ, et al., Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994 Aug 15;8(16):1897-909
J:26844 Sato TN, et al., Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 1995 Jul 6;376(6535):70-4
J:115217 Jones N, et al., Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function. EMBO Rep. 2001 May;2(5):438-45
J:155181 Winderlich M, et al., VE-PTP controls blood vessel development by balancing Tie-2 activity. J Cell Biol. 2009 May 18;185(4):657-71
J:155217 Fachinger G, et al., Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene. 1999 Oct 21;18(43):5948-53
J:200516 Jones N, et al., Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem. 1999 Oct 22;274(43):30896-905
J:237147 Souma T, et al., Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J Clin Invest. 2016 Jul 01;126(7):2575-87
J:262023 Morooka N, et al., Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017 Apr 14;120(8):1276-1288
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89