Sequence Detail

ID/Version

Q02395 Q05C61 Q8BGP9 Q569Z8 Q8BSJ7 Q6PG89 (UniProt | EBI)

Last sequence update: 2005-11-22
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Metal-response element-binding transcription factor 2;AltName: Full=Metal regulatory transcription factor 2;AltName: Full=Metal-response element DNA-binding protein M96;AltName: Full=Polycomb-like protein 2; Short=mPCl2;AltName: Full

Provider

SWISS-PROT

Sequence

Polypeptide 593 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mtf2	metal response element binding transcription factor 2	29	111	3	765

Sequence references in MGI

J:20197 Inouye C, et al., Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. DNA Cell Biol. 1994 Jul;13(7):731-42
J:39506 Remondelli P, et al., Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter. Biochem J. 1997 Apr 1;323(Pt 1):79-85
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:157068 Walker E, et al., Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010 Feb 5;6(2):153-66
J:170279 Li X, et al., Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol. 2011 Jan;31(2):351-64
J:171509 Casanova M, et al., Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells. Development. 2011 Apr;138(8):1471-82
J:183475 Hunkapiller J, et al., Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet. 2012 Mar;8(3):e1002576
J:196212 Ballare C, et al., Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012 Dec;19(12):1257-65