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Sequence Detail
ID/Version
Q01705 Q9QW58 Q61905 Q7TQ51 Q9R0X7 Q99JC2 Q3U3Y2 Q8K428 Q7TQ50 Q06007 Q7TQ52 Q3TZW2 (UniProt | EBI) Last sequence update: 2012-04-18
Last annotation update: 2019-07-31
Sequence
description
from provider
RecName: Full=Neurogenic locus notch homolog protein 1; Short=Notch 1;AltName: Full=Motch A {ECO:0000303|PubMed:8440332};AltName: Full=mT14;AltName: Full=p300;Contains: RecName: Full=Notch 1 extracellular truncation {ECO:0000303|PubMed:10882062};
Provider SWISS-PROT
Sequence
Polypeptide 2531 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Notch1 notch 1 258 121 9 64
Sequence references in MGI J:1679 Del Amo FF, et al., Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development. 1992 Jul;115(3):737-44
J:3293 Reaume AG, et al., Expression analysis of a Notch homologue in the mouse embryo. Dev Biol. 1992 Dec;154(2):377-87
J:3995 Lardelli M, et al., Motch A and motch B--two mouse Notch homologues coexpressed in a wide variety of tissues. Exp Cell Res. 1993 Feb;204(2):364-72
J:4071 del Amo FF, et al., Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. Genomics. 1993 Feb;15(2):259-64
J:4697 Kopan R, et al., Mouse notch: expression in hair follicles correlates with cell fate determination. J Cell Biol. 1993 May;121(3):631-41
J:20592 Nye JS, et al., An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development. 1994 Sep;120(9):2421-30
J:30499 Messerle M, et al., Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells. Cytokines Mol Ther. 1995 Jun;1(2):139-43
J:56518 Lee JS, et al., Murine leukemia provirus-mediated activation of the Notch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3. FEBS Lett. 1999 Jul 23;455(3):276-80
J:68965 Kishi N, et al., Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int J Dev Neurosci. 2001 Feb;19(1):21-35
J:84492 Tsuji H, et al., Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas. Carcinogenesis. 2003 Jul;24(7):1257-68
J:88983 Wu L, et al., Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. Gene. 2004 Mar 17;328:153-65
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:99826 Eiraku M, et al., DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci. 2005 Jul;8(7):873-80
J:139281 Chastagner P, et al., AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS One. 2008;3(7):e2735
J:183220 Coleman ML, et al., Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem. 2007 Aug 17;282(33):24027-38
J:183961 Zheng X, et al., Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3368-73
J:197487 Tiberi L, et al., BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Nat Neurosci. 2012 Dec;15(12):1627-35
J:198689 Benner EJ, et al., Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature. 2013 May 16;497(7449):369-73
J:214228 Weaver KL, et al., NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Cancer Res. 2014 Sep 1;74(17):4741-51
J:224744 Sakamoto K, et al., The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. J Biol Chem. 2002 Aug 16;277(33):29399-405
J:241496 Saha M, et al., Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Hum Mol Genet. 2017 Aug 1;26(15):2984-3000
J:243509 Kakuda S, et al., Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Dev Cell. 2017 Jan 23;40(2):193-201
J:245299 Puca L, et al., Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. J Cell Sci. 2013 Oct 01;126(Pt 19):4457-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory