Sequence Detail

ID/Version

Q01341 (UniProt | EBI)

Last sequence update: 1993-04-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Adenylate cyclase type 6; EC=4.6.1.1 {ECO:0000269|PubMed:1379717, ECO:0000269|PubMed:18071070, ECO:0000269|PubMed:20466003, ECO:0000269|PubMed:20864687, ECO:0000269|PubMed:23753526, ECO:0000269|PubMed:24363043};AltName: Full=ATP pyro

Provider

SWISS-PROT

Sequence

Polypeptide 1165 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adcy6	adenylate cyclase 6	46	104	4	11

Sequence references in MGI

J:1747 Yoshimura M, et al., Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6716-20
J:36274 Premont RT, et al., Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation. Endocrinology. 1992 Dec;131(6):2774-84
J:122415 Michalski N, et al., Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007 Jun 13;27(24):6478-88
J:143138 Tang T, et al., Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 1;117(1):61-9
J:161317 Chien CL, et al., Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6). FEBS Lett. 2010 Jul 2;584(13):2883-90
J:162338 Kwon RY, et al., Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells. FASEB J. 2010 Aug;24(8):2859-68
J:173554 Choi YH, et al., Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84
J:185899 Rieg T, et al., Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol. 2010 Dec;21(12):2059-68
J:210708 Lee KL, et al., Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo. FASEB J. 2014 Mar;28(3):1157-65
J:212781 Sabbatini ME, et al., Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation. J Physiol. 2013 Aug 1;591(Pt 15):3693-707
J:244482 Tang T, et al., Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice. J Am Coll Cardiol. 2010 Apr 06;55(14):1476-86
J:244672 Rees S, et al., Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease. J Am Soc Nephrol. 2014 Feb;25(2):232-7
J:244742 Fenton RA, et al., Renal phosphate wasting in the absence of adenylyl cyclase 6. J Am Soc Nephrol. 2014 Dec;25(12):2822-34
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89