Sequence Detail

ID/Version

Q01320 E9PX08 (UniProt | EBI)

Last sequence update: 2011-12-14
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=DNA topoisomerase 2-alpha; EC=5.6.2.2 {ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:1331984};AltName: Full=DNA topoisomerase II, alpha isozyme;

Provider

SWISS-PROT

Sequence

Polypeptide 1528 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Top2a	topoisomerase (DNA) II alpha	110	105	3	54

Sequence references in MGI

J:3098 Adachi N, et al., Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation. Nucleic Acids Res. 1992 Oct 25;20(20):5297-303
J:16448 McPherson JP, et al., Characterization of a DNA topoisomerase IIalpha gene rearrangement in adriamycin-resistant P388 leukemia: expression of a fusion messenger RNA transcript encoding topoisomerase IIalpha and the retinoic acid receptor alpha locus. Cancer Res. 1993 Dec 15;53(24):5885-9
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:217257 Ogawa Y, et al., Shikonin shortens the circadian period: possible involvement of Top2 inhibition. Biochem Biophys Res Commun. 2014 Jan 3;443(1):339-43
J:284005 Dokshin GA, et al., GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. Dev Cell. 2020 Jan 6;52(1):53-68.e6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89