Sequence Detail

ID/Version

Q00417 (UniProt | EBI)

Last sequence update: 2003-03-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription factor 7 {ECO:0000312|MGI:MGI:98507}; Short=TCF-7 {ECO:0000305};AltName: Full=T-cell-specific transcription factor 1 {ECO:0000303|PubMed:1827138}; Short=T-cell factor 1 {ECO:0000303|PubMed:1827138};

Provider

SWISS-PROT

Sequence

Polypeptide 419 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tcf7	transcription factor 7, T cell specific	42	131	3	20

Sequence references in MGI

J:11147 Oosterwegel M, et al., Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. J Exp Med. 1991 May 1;173(5):1133-42
J:35031 Van de Wetering M, et al., Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol Cell Biol. 1996 Mar;16(3):745-52
J:57721 Roose J, et al., Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science. 1999 Sep 17;285(5435):1923-6
J:107212 Ioannidis V, et al., The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival. Nat Immunol. 2001 Aug;2(8):691-7
J:117301 Melichar HJ, et al., Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Science. 2007 Jan 12;315(5809):230-3
J:196163 Malhotra N, et al., A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013 Apr 18;38(4):681-93
J:237943 Jia S, et al., Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Dev Biol. 2016 Dec 01;420(1):110-119
J:270295 Spidale NA, et al., Interleukin-17-Producing gammadelta T Cells Originate from SOX13(+) Progenitors that Are Independent of gammadeltaTCR Signaling. Immunity. 2018 Nov 20;49(5):857-872.e5