Sequence Detail

ID/Version

P98078 Q3U3K1 Q91W56 Q923E1 (UniProt | EBI)

Last sequence update: 2006-01-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Disabled homolog 2;AltName: Full=Adaptor molecule disabled-2;AltName: Full=Differentially expressed in ovarian carcinoma 2; Short=DOC-2;AltName: Full=Mitogen-responsive phosphoprotein;

Provider

SWISS-PROT

Sequence

Polypeptide 766 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dab2	disabled 2, mitogen-responsive phosphoprotein	118	126	4	8

Sequence references in MGI

J:37850 Xu XX, et al., Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem. 1995 Jun 9;270(23):14184-91
J:66719 Cho SY, et al., p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Biochem J. 2000 Dec 15;352 Pt 3:645-50
J:69667 Sheng Z, et al., Chromosomal location of murine disabled-2 gene and structural comparison with its human ortholog. Gene. 2001 May 2;268(1-2):31-9
J:74601 Rosenbauer F, et al., Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion. EMBO J. 2002 Feb 1;21(3):211-20
J:75911 Morris SM, et al., Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 2002 Apr 2;21(7):1555-64
J:79862 Yang DH, et al., Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol. 2002 Nov 1;251(1):27-44
J:85094 Homayouni R, et al., Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol Brain Res. 2003 Jul 23;115(2):121-9
J:85533 Yun M, et al., Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem. 2003 Sep 19;278(38):36572-81
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103399 Choi YJ, et al., Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN. Biochem Biophys Res Commun. 2005 Jan 21;326(3):594-9
J:103780 Maurer ME, et al., Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J Cell Sci. 2005 Nov 15;118(Pt 22):5345-55
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:182937 Penheiter SG, et al., Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2. Mol Biol Cell. 2010 Nov 15;21(22):4009-19
J:186107 Mulkearns EE, et al., FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. Mol Biol Cell. 2012 Apr;23(7):1330-42
J:188901 Maurer ME, et al., The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH. J Cell Sci. 2006 Oct 15;119(Pt 20):4235-46
J:188905 Hocevar BA, et al., Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway. J Biol Chem. 2005 Jul 8;280(27):25920-7
J:188906 Prunier C, et al., Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J Biol Chem. 2005 Apr 29;280(17):17540-8
J:188907 Mishra SK, et al., Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J. 2002 Sep 16;21(18):4915-26
J:188910 Morris SM, et al., Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001 Feb;2(2):111-23
J:189999 Kowanetz K, et al., Dab2 links CIN85 with clathrin-mediated receptor internalization. FEBS Lett. 2003 Nov 6;554(1-2):81-7
J:190009 Xu XX, et al., Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene. 1998 Mar 26;16(12):1561-9
J:190256 Teckchandani A, et al., The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16
J:201942 Jiang Y, et al., Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. Oncogene. 2009 Aug 20;28(33):2999-3007
J:230357 Calderwood DA, et al., Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2272-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89