Sequence Detail

ID/Version

P97929 P97383 O35922 F8VPU5 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Breast cancer type 2 susceptibility protein homolog {ECO:0000305};AltName: Full=Fanconi anemia group D1 protein homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 3329 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Brca2	breast cancer 2, early onset	106	112	3	53

Sequence references in MGI

J:36562 Rajan JV, et al., Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc Natl Acad Sci U S A. 1996 12;93(23):13078-83
J:38616 Connor F, et al., Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene. Hum Mol Genet. 1997 Feb;6(2):291-300
J:39116 Sharan SK, et al., Murine Brca2: sequence, map position, and expression pattern. Genomics. 1997 Mar 1;40(2):234-41
J:41357 McAllister KA, et al., Genetic mapping of the Brca2 breast cancer susceptibility gene on mouse chromosome 5. Mamm Genome. 1997 Jul;8(7):540-1
J:41969 McAllister KA, et al., Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene. Cancer Res. 1997 Aug 1;57(15):3121-5
J:114800 Yang H, et al., BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science. 2002 Sep 13;297(5588):1837-48
J:273173 Zhang J, et al., A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. Nat Commun. 2019 Feb 13;10(1):722
J:291970 Takemoto K, et al., Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination. Cell Rep. 2020 May 26;31(8):107686
J:292036 Zhang J, et al., The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Nat Commun. 2020 Apr 28;11(1):2055
J:294372 Brandsma I, et al., HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. Cell Rep. 2019 Jun 25;27(13):3790-3798.e7
J:303558 Felipe-Medina N, et al., A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1. Elife. 2020 Aug 26;9:e56996