Sequence Detail

ID/Version

P97864 O08669 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Caspase-7 {ECO:0000303|PubMed:9070923}; Short=CASP-7 {ECO:0000303|PubMed:9070923}; EC=3.4.22.60 {ECO:0000269|PubMed:25231987, ECO:0000269|PubMed:35705808};AltName: Full=Apoptotic protease Mch-3;AltName: Full=Cysteine protease

Provider

SWISS-PROT

Sequence

Polypeptide 303 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casp7	caspase 7	83	105	3	9

Sequence references in MGI

J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
J:38565 Juan TS, et al., Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3. Genomics. 1997 Feb 15;40(1):86-93
J:105496 Lakhani SA, et al., Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science. 2006 Feb 10;311(5762):847-51
J:146876 Lamkanfi M, et al., Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood. 2009 Mar 19;113(12):2742-5
J:188026 Erener S, et al., Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes. Mol Cell. 2012 Apr 27;46(2):200-11
J:195378 Cassidy SK, et al., Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response. PLoS Pathog. 2012;8(7):e1002628
J:274136 Ning X, et al., Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3. Mol Cell. 2019 Apr 4;74(1):19-31.e7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306586 Suzuki J, et al., Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. J Biol Chem. 2014 Oct 31;289(44):30257-30267
J:324736 Goncalves AV, et al., Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila. PLoS Pathog. 2019 Jun;15(6):e1007886
J:326897 Nozaki K, et al., Caspase-7 activates ASM to repair gasdermin and perforin pores. Nature. 2022 Jun;606(7916):960-967
J:326901 Lamkanfi M, et al., Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics. 2008 Dec;7(12):2350-63