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Sequence Detail
ID/Version
P97807 Q9DCX0 Q3UIA9 Q99JL0 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2019-12-11
Sequence
description
from provider
RecName: Full=Fumarate hydratase, mitochondrial {ECO:0000303|PubMed:17418408}; Short=Fumarase {ECO:0000303|PubMed:9032278}; EC=4.2.1.2 {ECO:0000305|PubMed:23643539};AltName: Full=EF-3;Flags: Precursor;
Provider SWISS-PROT
Sequence
Polypeptide 507 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Fh1 fumarate hydratase 1 35 79 9 16
Sequence references in MGI J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120969 Pollard PJ, et al., Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell. 2007 Apr;11(4):311-9
J:177485 Adam J, et al., Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling. Cancer Cell. 2011 Oct 18;20(4):524-37
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:198486 Adam J, et al., A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia. Cell Rep. 2013 May 30;3(5):1440-8
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory