Sequence Detail

ID/Version

P97797 O08907 O88555 P97796 O35924 Q9WTN4 E9QPT7 Q8R559 O88556 A0A0R4J1Z7 Q9QX57 E0CYM8 (UniProt | EBI)

Last sequence update: 2019-05-08
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein phosphatase non-receptor type substrate 1; Short=SHP substrate 1; Short=SHPS-1;AltName: Full=Brain Ig-like molecule with tyrosine-based activation motifs; Short=Bit;AltName: Full=CD172 antigen-like fa

Provider

SWISS-PROT

Sequence

Polypeptide 513 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sirpa	signal-regulatory protein alpha	61	105	3	24

Sequence references in MGI

J:38263 Yamao T, et al., Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes. Biochem Biophys Res Commun. 1997 Feb 3;231(1):61-7
J:39360 Ohnishi H, et al., BIT (Bit) maps to mouse chromosome 2. Genomics. 1997 Mar 15;40(3):504-6
J:44085 Comu S, et al., The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family. J Neurosci. 1997 Nov 15;17(22):8702-10
J:49645 Veillette A, et al., High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages. J Biol Chem. 1998 Aug 28;273(35):22719-28
J:52073 Jiang P, et al., Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem. 1999 Jan 8;274(2):559-62
J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:166502 Nakaishi A, et al., Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47. J Mol Biol. 2008 Jan 18;375(3):650-60
J:273377 Sarute N, et al., TRIM2, a novel member of the antiviral family, limits New World arenavirus entry. PLoS Biol. 2019 Feb;17(2):e3000137
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89