Sequence Detail

ID/Version

P97793 E9QKV3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=ALK tyrosine kinase receptor {ECO:0000305}; EC=2.7.10.1 {ECO:0000250|UniProtKB:Q9UM73};AltName: Full=Anaplastic lymphoma kinase {ECO:0000303|PubMed:9053841};AltName: CD_antigen=CD246;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1621 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alk	anaplastic lymphoma kinase	62	107	4	21

Sequence references in MGI

J:38743 Iwahara T, et al., Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene. 1997 Jan 30;14(4):439-49
J:109486 Vernersson E, et al., Characterization of the expression of the ALK receptor tyrosine kinase in mice. Gene Expr Patterns. 2006 Jun;6(5):448-61
J:146467 Degoutin J, et al., ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction. Eur J Neurosci. 2009 Jan;29(2):275-86
J:226526 Bilsland JG, et al., Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications. Neuropsychopharmacology. 2008 Feb;33(3):685-700
J:226591 Weiss JB, et al., Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis. Pharmacol Biochem Behav. 2012 Jan;100(3):566-74
J:281259 Tang C, et al., Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. 2018 Nov 14;
J:291736 Orthofer M, et al., Identification of ALK in Thinness. Cell. 2020 Jun 11;181(6):1246-1262.e22