Sequence Detail

ID/Version

P97767 G5E864 O08818 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein phosphatase EYA1 {ECO:0000305}; EC=3.1.3.16 {ECO:0000269|PubMed:14628052}; EC=3.1.3.48 {ECO:0000269|PubMed:14628052};AltName: Full=Eyes absent homolog 1;

Provider

SWISS-PROT

Sequence

Polypeptide 591 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eya1	EYA transcriptional coactivator and phosphatase 1	103	170	3	16

Sequence references in MGI

J:38379 Xu PX, et al., Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997 Jan;124(1):219-31
J:38771 Abdelhak S, et al., A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat Genet. 1997 Feb;15(2):157-64
J:52368 Borsani G, et al., EYA4, a novel vertebrate gene related to Drosophila eyes absent. Hum Mol Genet. 1999 Jan;8(1):11-23
J:54408 Johnson KR, et al., Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome. Hum Mol Genet. 1999 Apr;8(4):645-53
J:57313 Xu PX, et al., Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
J:86608 Rayapureddi JP, et al., Eyes absent represents a class of protein tyrosine phosphatases. Nature. 2003 Nov 20;426(6964):295-8
J:86619 Li X, et al., Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54
J:103131 Purcell P, et al., Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns. 2005 Dec;6(1):110-8
J:112841 Alkuraya FS, et al., SUMO1 haploinsufficiency leads to cleft lip and palate. Science. 2006 Sep 22;313(5794):1751
J:113793 Ohto H, et al., Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol. 1999 Oct;19(10):6815-24
J:119948 Grifone R, et al., Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 2007 Feb 15;302(2):602-16
J:147286 Cook PJ, et al., Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature. 2009 Apr 2;458(7238):591-6