Sequence Detail

ID/Version

P97742 O35288 Q8C7H8 Q8BP98 Q80SW3 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Carnitine O-palmitoyltransferase 1, liver isoform; Short=CPT1-L; EC=2.3.1.21 {ECO:0000269|PubMed:16169268, ECO:0000269|PubMed:17030509};AltName: Full=Carnitine O-palmitoyltransferase I, liver isoform; Short=CPT I;

Provider

SWISS-PROT

Sequence

Polypeptide 773 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cpt1a	carnitine palmitoyltransferase 1a, liver	79	111	6	43

Sequence references in MGI

J:32866 Uenaka R, et al., Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice. J Biochem. 1996 Mar;119(3):533-40
J:48972 Cox KB, et al., Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene. Mamm Genome. 1998 Aug;9(8):608-10
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101934 Nyman LR, et al., Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouse. Mol Genet Metab. 2005 Sep-Oct;86(1-2):179-87
J:245050 Nyman LR, et al., Long term effects of high fat or high carbohydrate diets on glucose tolerance in mice with heterozygous carnitine palmitoyltransferase-1a (CPT-1a) deficiency: Diet influences on CPT1a deficient mice. Nutr Diabetes. 2011 Aug 22;1:e14
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292522 Deberardinis RJ, et al., Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J Biol Chem. 2006 Dec 8;281(49):37372-80