Sequence Detail

ID/Version

P97479 Q5MJ57 E9QLP7 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Unconventional myosin-VIIa;

Provider

SWISS-PROT

Sequence

Polypeptide 2215 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Myo7a	myosin VIIA	129	185	4	30

Sequence references in MGI

J:23257 Gibson F, et al., A type VII myosin encoded by the mouse deafness gene shaker-1. Nature. 1995 Mar 2;374(6517):62-4
J:49926 Mburu P, et al., Mutation analysis of the mouse myosin VIIA deafness gene. Genes Funct. 1997 Jun;1(3):191-203
J:80040 Fukuda M, et al., Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. J Biol Chem. 2002 Nov 8;277(45):43096-103
J:95920 Delprat B, et al., Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly. Hum Mol Genet. 2005 Feb 1;14(3):401-10
J:99802 Etournay R, et al., PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa. J Cell Sci. 2005 Jul 1;118(Pt 13):2891-9
J:102099 Belyantseva IA, et al., Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia. Nat Cell Biol. 2005 Feb;7(2):148-56
J:105750 Senften M, et al., Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J Neurosci. 2006 Feb 15;26(7):2060-71
J:122415 Michalski N, et al., Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007 Jun 13;27(24):6478-88
J:173770 Lopes VS, et al., The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65. Hum Mol Genet. 2011 Jul 1;20(13):2560-70
J:174394 Grati M, et al., Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11476-81
J:236403 Morgan CP, et al., PDZD7-MYO7A complex identified in enriched stereocilia membranes. Elife. 2016 Aug 15;5:e18312
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89