Sequence Detail

ID/Version

P97477 Q8C3H8 Q91YU4 O35624 (UniProt | EBI)

Last sequence update: 1997-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Aurora kinase A {ECO:0000312|MGI:MGI:894678}; EC=2.7.11.1 {ECO:0000250|UniProtKB:P04198};AltName: Full=Aurora 2 {ECO:0000250|UniProtKB:O14965};AltName: Full=Aurora/IPL1-related kinase 1 {ECO:0000250|UniProtKB:O14965}; Short=A

Provider

SWISS-PROT

Sequence

Polypeptide 395 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aurka	aurora kinase A	135	111	3	31

Sequence references in MGI

J:41165 Yanai A, et al., ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis. Oncogene. 1997 Jun 19;14(24):2943-50
J:46390 Shindo M, et al., cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Biochem Biophys Res Commun. 1998 Mar 6;244(1):285-92
J:97428 Yu X, et al., Chfr is required for tumor suppression and Aurora A regulation. Nat Genet. 2005 Apr;37(4):401-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:144769 Gopalan G, et al., A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators. J Cell Biol. 1997 Aug 11;138(3):643-56
J:145744 Cowley DO, et al., Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol. 2009 Feb;29(4):1059-71
J:158132 Mori D, et al., An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. Nat Cell Biol. 2009 Sep;11(9):1057-68
J:162627 Kinzel D, et al., Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010 Jul 20;19(1):66-77
J:184734 Coon TA, et al., Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Cell Cycle. 2012 Feb 15;11(4):721-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319955 Lee SY, et al., Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes. Cell Cycle. 2016 Dec;15(23):3296-3305