Sequence Detail

ID/Version

P97474 O70336 Q9JLA0 Q9QXB8 O08646 Q9R1V9 P97933 Q9Z141 (UniProt | EBI)

Last sequence update: 1999-07-15
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Pituitary homeobox 2 {ECO:0000305};AltName: Full=ALL1-responsive protein ARP1 {ECO:0000303|PubMed:9539779};AltName: Full=BRX1 homeoprotein;AltName: Full=Bicoid-related homeobox protein 1 {ECO:0000303|PubMed:9347917};AltName: Full=Homeobox pr

Provider

SWISS-PROT

Sequence

Polypeptide 317 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pitx2	paired-like homeodomain transcription factor 2	125	289	3	24

Sequence references in MGI

J:36998 Semina EV, et al., Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat Genet. 1996 Dec;14(4):392-9
J:39014 Gage PJ, et al., Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation. Hum Mol Genet. 1997 Mar;6(3):457-64
J:43579 Kitamura K, et al., Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation. Mech Dev. 1997 Sep;67(1):83-96
J:47444 Arakawa H, et al., Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4573-8
J:59002 Schweickert A, et al., Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry. Mech Dev. 2000 Jan;90(1):41-51
J:69271 Nicholson LF, et al., Cloning and expression of Munc 30: a member of the paired -like homeodomain gene family. Cell Biol Int. 2001;25(4):351-65
J:92872 Bamforth SD, et al., Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet. 2004 Dec;36(11):1189-96
J:186376 Gherzi R, et al., Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation. Cell Death Differ. 2010 Jun;17(6):975-83