Sequence Detail

ID/Version

P97454 P70341 Q810K0 (UniProt | EBI)

Last sequence update: 2001-05-04
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mothers against decapentaplegic homolog 5; Short=MAD homolog 5; Short=Mothers against DPP homolog 5;AltName: Full=Dwarfin-C; Short=Dwf-C;AltName: Full=SMAD family member 5; Short=SMAD 5; Short=Smad5;

Provider

SWISS-PROT

Sequence

Polypeptide 465 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smad5	SMAD family member 5	91	190	3	19

Sequence references in MGI

J:38636 Meersseman G, et al., The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation. Mech Dev. 1997 Jan;61(1-2):127-40
J:51722 Yingling JM, et al., Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8940-4
J:53289 Yang X, et al., Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999 Apr;126(8):1571-80
J:61302 Weinstein M, et al., Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):49-58
J:79484 Jiao K, et al., Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1. Mol Cell Biol. 2002 Nov;22(21):7633-44
J:81128 Liu B, et al., Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis. Blood. 2003 Jan 1;101(1):124-33
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:170631 Hisa I, et al., Parathyroid Hormone-responsive Smad3-related Factor, Tmem119, Promotes Osteoblast Differentiation and Interacts with the Bone Morphogenetic Protein-Runx2 Pathway. J Biol Chem. 2011 Mar 18;286(11):9787-96
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89