Sequence Detail

ID/Version

P97438 Q4VQI2 (UniProt | EBI)

Last sequence update: 2014-04-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Potassium channel subfamily K member 2;AltName: Full=Outward rectifying potassium channel protein TREK-1;AltName: Full=TREK-1 K(+) channel subunit {ECO:0000303|PubMed:10321245, ECO:0000303|PubMed:24496152};AltName: Full=Two pore potassium ch

Provider

SWISS-PROT

Sequence

Polypeptide 426 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnk2	potassium channel, subfamily K, member 2	102	105	4	10

Sequence references in MGI

J:37545 Fink M, et al., Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J. 1996 Dec 16;15(24):6854-62
J:119946 Sandoz G, et al., AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels. EMBO J. 2006 Dec 13;25(24):5864-72
J:184566 Froese A, et al., Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. J Clin Invest. 2012 Mar 1;122(3):1119-30
J:188266 Woo DH, et al., TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation. Cell. 2012 Sep 28;151(1):25-40
J:206720 Hwang EM, et al., A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes. Nat Commun. 2014 Feb 5;5:3227
J:229320 Schindler RF, et al., POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking. J Clin Invest. 2016 Jan;126(1):239-53
J:232118 Blin S, et al., Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4200-5
J:270313 Royal P, et al., Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron. 2019 Jan 16;101(2):232-245.e6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:352573 Sandoz G, et al., Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron. 2012 Jun 21;74(6):1005-14