Sequence Detail

ID/Version

P97377 O55105 (UniProt | EBI)

Last sequence update: 2000-05-30
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cyclin-dependent kinase 2; EC=2.7.11.22 {ECO:0000269|PubMed:23853094};AltName: Full=Cell division protein kinase 2;

Provider

SWISS-PROT

Sequence

Polypeptide 346 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdk2	cyclin dependent kinase 2	130	117	3	31

Sequence references in MGI

J:85230 Ortega S, et al., Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet. 2003 Sep;35(1):25-31
J:86203 Berthet C, et al., Cdk2 knockout mice are viable. Curr Biol. 2003 Oct 14;13(20):1775-85
J:168213 Wu CL, et al., Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. Cancer Res. 2001 Oct 1;61(19):7325-32
J:210466 Liu P, et al., Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24;508(7497):541-5
J:219103 Wang GL, et al., Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev. 2004 Apr 15;18(8):912-25
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89