Sequence Detail

ID/Version

P97350 B2RSX3 (UniProt | EBI)

Last sequence update: 1997-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Plakophilin-1;

Provider

SWISS-PROT

Sequence

Polypeptide 728 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pkp1	plakophilin 1	66	105	3	11

Sequence references in MGI

J:113898 Hofmann I, et al., Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. J Cell Sci. 2000 Jul;113(Pt 13):2471-83
J:136451 Sklyarova T, et al., Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol. 2008 Jun;128(6):1375-85
J:233599 Rietscher K, et al., Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo. J Invest Dermatol. 2016 Jul;136(7):1471-8
J:238141 Keil R, et al., Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. J Invest Dermatol. 2016 Oct;136(10):2022-9
J:243578 Lee P, et al., Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. EMBO J. 2017 Jul 03;36(13):1963-1980
J:263053 Rietscher K, et al., 14-3-3 proteins regulate desmosomal adhesion via plakophilins. J Cell Sci. 2018 May 22;131(10):jcs212191
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:349400 Miyazaki K, et al., Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast Differentiation. PLoS One. 2016;11(3):e0152206
J:352404 Fuchs M, et al., Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering. Cell Mol Life Sci. 2019 Sep;76(17):3465-3476