Sequence Detail

ID/Version

P97318 A2A966 A2A965 P97316 A2A970 A2A963 P97317 A2A964 A2A967 Q9DAP9 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Disabled homolog 1 {ECO:0000305}; Short=mDab1 {ECO:0000303|PubMed:9009273};

Provider

SWISS-PROT

Sequence

Polypeptide 588 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dab1	disabled 1	79	182	4	31

Sequence references in MGI

J:38446 Howell BW, et al., Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J. 1997 Jan 2;16(1):121-32
J:43504 Sheldon M, et al., Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice [see comments]. Nature. 1997 Oct 16;389(6652):730-3
J:43647 Howell BW, et al., Neuronal position in the developing brain is regulated by mouse disabled-1 [see comments]. Nature. 1997 Oct 16;389(6652):733-7
J:77532 Keshvara L, et al., Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. J Neurosci. 2002 Jun 15;22(12):4869-77
J:79475 Howell BW, et al., Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development. Curr Biol. 2000 Jul 27-Aug 10;10(15):877-85
J:82567 Park TJ, et al., Inhibition of ubiquitin ligase Siah-1A by disabled-1. Biochem Biophys Res Commun. 2003 Mar 21;302(4):671-8
J:85533 Yun M, et al., Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem. 2003 Sep 19;278(38):36572-81
J:90089 Ballif BA, et al., Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol. 2004 Apr 6;14(7):606-10
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:109820 Arnaud L, et al., Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol. 2003 Jan 8;13(1):9-17
J:205551 Simo S, et al., Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411
J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
J:349403 Feng L, et al., Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development. Genes Dev. 2007 Nov 1;21(21):2717-30