Sequence Detail

ID/Version

P97313 Q9Z341 E9QN15 Q8C2A7 O88187 P97928 Q3V2W8 Q307W9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=DNA-dependent protein kinase catalytic subunit; Short=DNA-PK catalytic subunit; Short=DNA-PKcs; EC=2.7.11.1 {ECO:0000250|UniProtKB:P78527};AltName: Full=p460;

Provider

SWISS-PROT

Sequence

Polypeptide 4128 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkdc	protein kinase, DNA activated, catalytic polypeptide	170	99	3	61

Sequence references in MGI

J:35350 Danska JS, et al., Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol. 1996 Oct;16(10):5507-17
J:35393 Blunt T, et al., Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10285-90
J:37619 Hamatani K, et al., Cloning and chromosomal mapping of the mouse DNA-dependent protein kinase gene. Immunogenetics. 1996;45(1):1-5
J:39329 Araki R, et al., Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2438-43
J:43493 Fujimori A, et al., The murine DNA-PKcs gene consists of 86 exons dispersed in more than 250 kb. Genomics. 1997 Oct 1;45(1):194-9
J:47726 Fukumura R, et al., Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint. J Biol Chem. 1998 May 22;273(21):13058-64
J:49582 Saito T, et al., Mouse cdc21 only 0.5 kb upstream from dna-pkcs in a head-to-head organization: an implication of co-evolution of ATM family members and cell cycle regulating genes. Mamm Genome. 1998 Sep;9(9):769-72
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111398 Espejel S, et al., Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J. 2002 Nov 15;21(22):6275-87
J:116399 Kharbanda S, et al., Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature. 1997 Apr 17;386(6626):732-5
J:168151 Kornberg MD, et al., GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol. 2010 Nov;12(11):1094-100
J:207239 Gao P, et al., Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length. J Biol Chem. 2013 Dec 6;288(49):35277-86
J:287062 Shao Z, et al., DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Nature. 2020 Mar;579(7798):291-296
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89