Sequence Detail

ID/Version

P97305 Q60896 (UniProt | EBI)

Last sequence update: 1997-05-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Nuclear factor of activated T-cells, cytoplasmic 3 {ECO:0000305}; Short=NF-ATc3; Short=NFATc3 {ECO:0000303|PubMed:7650004};AltName: Full=NFATx {ECO:0000303|PubMed:9017603};AltName: Full=T-cell transcription factor NFAT4 {ECO:

Provider

SWISS-PROT

Sequence

Polypeptide 1075 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nfatc3	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3	84	112	4	54

Sequence references in MGI

J:28305 Ho SN, et al., NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem. 1995 Aug 25;270(34):19898-907
J:38327 Liu J, et al., Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization. Mol Biol Cell. 1997 Jan;8(1):157-70
J:79608 Wilkins BJ, et al., Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth. Mol Cell Biol. 2002 Nov;22(21):7603-13
J:84138 Bushdid PB, et al., NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res. 2003 Jun 27;92(12):1305-13
J:119549 Yang XY, et al., Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition. Dev Biol. 2007 Mar 15;303(2):825-37
J:141917 Cante-Barrett K, et al., Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007 Jul 1;179(1):103-10
J:163869 de Frutos S, et al., NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H356-63
J:175305 Lee HL, et al., High extracellular calcium-induced NFATc3 regulates the expression of receptor activator of NF-kappaB ligand in osteoblasts. Bone. 2011 Aug;49(2):242-9
J:175668 de Frutos S, et al., Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries. Am J Physiol Cell Physiol. 2011 Aug;301(2):C441-50
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343111 Ranjan R, et al., The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis. J Innate Immun. 2014;6(6):754-64
J:343388 Manukyan I, et al., Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli. J Cell Mol Med. 2010 Jun;14(6B):1707-16