ID/Version |
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Sequence description from provider |
RecName: Full=Nuclear factor of activated T-cells, cytoplasmic 3 {ECO:0000305}; Short=NF-ATc3; Short=NFATc3 {ECO:0000303|PubMed:7650004};AltName: Full=NFATx {ECO:0000303|PubMed:9017603};AltName: Full=T-cell transcription factor NFAT4 {ECO: | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
1075
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:28305
Ho SN, et al., NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem. 1995 Aug 25;270(34):19898-907
J:38327 Liu J, et al., Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization. Mol Biol Cell. 1997 Jan;8(1):157-70 J:79608 Wilkins BJ, et al., Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth. Mol Cell Biol. 2002 Nov;22(21):7603-13 J:84138 Bushdid PB, et al., NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res. 2003 Jun 27;92(12):1305-13 J:119549 Yang XY, et al., Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition. Dev Biol. 2007 Mar 15;303(2):825-37 J:141917 Cante-Barrett K, et al., Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007 Jul 1;179(1):103-10 J:163869 de Frutos S, et al., NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H356-63 J:175305 Lee HL, et al., High extracellular calcium-induced NFATc3 regulates the expression of receptor activator of NF-kappaB ligand in osteoblasts. Bone. 2011 Aug;49(2):242-9 J:175668 de Frutos S, et al., Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries. Am J Physiol Cell Physiol. 2011 Aug;301(2):C441-50 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 J:343111 Ranjan R, et al., The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis. J Innate Immun. 2014;6(6):754-64 J:343388 Manukyan I, et al., Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli. J Cell Mol Med. 2010 Jun;14(6B):1707-16 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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