Sequence Detail

ID/Version

P83741 Q6VYA0 Q6A083 Q3UZP3 A6H6V1 B2RRJ7 Q6IFS6 B7ZNJ4 (UniProt | EBI)

Last sequence update: 2010-11-30
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase WNK1 {ECO:0000305}; EC=2.7.11.1 {ECO:0000250|UniProtKB:Q9H4A3};AltName: Full=Protein kinase lysine-deficient 1 {ECO:0000312|MGI:MGI:2442092};AltName: Full=Protein kinase with no lysine 1 {ECO:0000303|P

Provider

SWISS-PROT

Sequence

Polypeptide 2377 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Wnk1	WNK lysine deficient protein kinase 1	117	109	4	44

Sequence references in MGI

J:84760 Yang CL, et al., WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest. 2003 Apr;111(7):1039-45
J:85860 O'Reilly M, et al., WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain. J Am Soc Nephrol. 2003 Oct;14(10):2447-56
J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114792 Wilson FH, et al., Human hypertension caused by mutations in WNK kinases. Science. 2001 Aug 10;293(5532):1107-12
J:137721 Shekarabi M, et al., Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II. J Clin Invest. 2008 Jul;118(7):2496-505
J:152906 Xie J, et al., Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol. 2009 Sep;175(3):1315-27
J:168700 Liu Z, et al., Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet. 2011 Mar 1;20(5):855-66
J:172037 Yang D, et al., IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011 Mar 1;121(3):956-65
J:220505 Park S, et al., Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:335663 Choate KA, et al., WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):663-8