Sequence Detail

ID/Version

P81122 B9EJW3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Insulin receptor substrate 2; Short=IRS-2;AltName: Full=4PS;

Provider

SWISS-PROT

Sequence

Polypeptide 1321 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irs2	insulin receptor substrate 2	85	100	4	11

Sequence references in MGI

J:38317 Sun XJ, et al., Role of IRS-2 in insulin and cytokine signalling. Nature. 1995 Sep 14;377(6545):173-7
J:46134 Withers DJ, et al., Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998 Feb 26;391(6670):900-4
J:66427 Farhang-Fallah J, et al., Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. J Biol Chem. 2000 Dec 22;275(51):40492-7
J:125126 Podcheko A, et al., Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Mol Cell Biol. 2007 Sep;27(18):6484-96
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89