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Sequence Detail
P80560 O09134 Q1RLJ1 P70328 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2018-03-28
from provider
RecName: Full=Receptor-type tyrosine-protein phosphatase N2; Short=R-PTP-N2; EC=3.1.3.-; EC=;AltName: Full=PTP IA-2beta {ECO:0000303|PubMed:8637868};AltName: Full=Phogrin {ECO:0000303|PubMed:16262730, ECO:0000303|PubMed:212
Polypeptide 1001 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 25 7 7 6
Sequence references in MGI J:34182 Chiang MK, et al., PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development. 1996 Jul;122(7):2239-50
J:34575 Lu J, et al., Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2307-11
J:91889 Kubosaki A, et al., Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes. 2004 Jul;53(7):1684-91
J:129445 Kubosaki A, et al., Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility. Endocrinology. 2006 Feb;147(2):811-5
J:144745 Kim SM, et al., Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway. Am J Physiol Renal Physiol. 2009 Feb;296(2):F382-9
J:148933 Nishimura T, et al., Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan. Neuroscience. 2009 Mar 17;159(2):427-37
J:174841 Cai T, et al., Deletion of Ia-2 and/or Ia-2beta in mice decreases insulin secretion by reducing the number of dense core vesicles. Diabetologia. 2011 Sep;54(9):2347-57
J:196050 Cape A, et al., Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic beta-cells. Cell Mol Life Sci. 2012 Apr;69(8):1305-17
J:200322 Gross S, et al., Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity. J Biol Chem. 2002 Dec 13;277(50):48139-45

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last database update
MGI 6.11
The Jackson Laboratory