Sequence Detail

ID/Version

P79621 Q9TPP1 O46787 O78109 O78036 Q31115 (UniProt | EBI)

Last sequence update: 2003-04-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=MHC class II transactivator {ECO:0000305}; Short=CIITA; EC=2.3.1.- {ECO:0000250|UniProtKB:P33076}; EC=2.7.11.1 {ECO:0000250|UniProtKB:P33076};

Provider

SWISS-PROT

Sequence

Polypeptide 1155 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ciita	class II transactivator	49	99	3	15

Sequence references in MGI

J:32551 Panelli MC, et al., Interferon gamma (IFNgamma) gene transfer of an EMT6 tumor that is poorly responsive to IFNgamma stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC. Cancer Immunol Immunother. 1996 Feb;42(2):99-107
J:38736 Sims TN, et al., Mouse class II transactivator: cDNA sequence and amino acid comparison with the human class II transactivator. Immunogenetics. 1997;45(3):220-2
J:40766 Muhlethaler-Mottet A, et al., Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 1997 May 15;16(10):2851-60
J:297334 Bruchez A, et al., MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. Science. 2020 Oct 9;370(6513):241-247
J:338142 He K, et al., Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell. 2023 Jul 6;186(14):3033-3048.e20