Sequence Detail

ID/Version

P70704 Q8BR88 (UniProt | EBI)

Last sequence update: 2014-07-09
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phospholipid-transporting ATPase IA {ECO:0000305}; EC=7.6.2.1 {ECO:0000269|PubMed:20224745};AltName: Full=ATPase class I type 8A member 1;AltName: Full=Chromaffin granule ATPase II;AltName: Full=P4-ATPase flippase complex alpha subun

Provider

SWISS-PROT

Sequence

Polypeptide 1164 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atp8a1	ATPase phospholipid transporting 8A1	69	103	3	11

Sequence references in MGI

J:47134 Halleck MS, et al., Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Genome Res. 1998 Apr;8(4):354-61
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108266 Paterson JK, et al., Lipid specific activation of the murine P4-ATPase Atp8a1 (ATPase II). Biochemistry. 2006 Apr 25;45(16):5367-76
J:108558 Soupene E, et al., Identification of an erythroid ATP-dependent aminophospholipid transporter. Br J Haematol. 2006 May;133(4):436-8
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:179412 Levano K, et al., Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning. J Neurochem. 2012 Jan;120(2):302-13
J:197107 Kato U, et al., Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. J Biol Chem. 2013 Feb 15;288(7):4922-34
J:255476 Kerr DJ, et al., Aberrant hippocampal Atp8a1 levels are associated with altered synaptic strength, electrical activity, and autistic-like behavior. Biochim Biophys Acta. 2016 Sep;1862(9):1755-65
J:281243 Soupene E, et al., ATP8A1 activity and phosphatidylserine transbilayer movement. J Receptor Ligand Channel Res. 2008;1:1-10
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296078 Jing W, et al., Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets. Blood Adv. 2019 Feb 12;3(3):219-229