Sequence Detail

ID/Version

P70677 Q8CHV5 O08668 Q9QWI4 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Caspase-3; Short=CASP-3; EC=3.4.22.56 {ECO:0000269|PubMed:12124386, ECO:0000269|PubMed:25231987, ECO:0000269|PubMed:33725486};AltName: Full=Apopain;AltName: Full=Cysteine protease CPP32 {ECO:0000303|PubMed:8934524}; S

Provider

SWISS-PROT

Sequence

Polypeptide 277 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casp3	caspase 3	127	470	4	25

Sequence references in MGI

J:34911 Juan TS, et al., Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3. Oncogene. 1996 Aug 15;13(4):749-55
J:36821 Kuida K, et al., Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 1996 Nov 28;384(6607):368-72
J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
J:38625 Mukasa T, et al., Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF. Biochem Biophys Res Commun. 1997 Feb 24;231(3):770-4
J:79113 Xu J, et al., The role of Asp-462 in regulating Akt activity. J Biol Chem. 2002 Sep 20;277(38):35561-6
J:105496 Lakhani SA, et al., Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science. 2006 Feb 10;311(5762):847-51
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:274136 Ning X, et al., Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3. Mol Cell. 2019 Apr 4;74(1):19-31.e7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:305632 Maruoka M, et al., Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. Mol Cell. 2021 Apr 1;81(7):1397-1410.e9
J:306586 Suzuki J, et al., Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. J Biol Chem. 2014 Oct 31;289(44):30257-30267