Sequence Detail

ID/Version

P70662 Q71V68 Q1EQX2 O55204 (UniProt | EBI)

Last sequence update: 2007-09-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=LIM domain-binding protein 1; Short=LDB-1;AltName: Full=Carboxyl-terminal LIM domain-binding protein 2; Short=CLIM-2;AltName: Full=LIM domain-binding factor CLIM2; Short=mLdb1;AltName: Full=Nuclear LIM interactor;

Provider

SWISS-PROT

Sequence

Polypeptide 411 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ldb1	LIM domain binding 1	92	117	4	100

Sequence references in MGI

J:41049 Bach I, et al., A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev. 1997 Jun 1;11(11):1370-80
J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
J:41553 Jurata LW, et al., Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc Natl Acad Sci U S A. 1996 15;93(21):11693-8
J:46276 Yamashita T, et al., Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1. Genomics. 1998 Feb 15;48(1):87-92
J:51686 Sugihara TM, et al., Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15418-23
J:54184 Bertuzzi S, et al., Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex. Mech Dev. 1999;81(1-2):193-8
J:118838 Breen JJ, et al., Interactions between LIM domains and the LIM domain-binding protein Ldb1. J Biol Chem. 1998 Feb 20;273(8):4712-7
J:118839 Visvader JE, et al., The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13707-12
J:118840 Jurata LW, et al., Functional analysis of the nuclear LIM domain interactor NLI. Mol Cell Biol. 1997 Oct;17(10):5688-98
J:150700 Kimura N, et al., A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. J Biochem. 1999 Jul;126(1):180-7
J:161034 Ostendorff HP, et al., Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature. 2002 Mar 7;416(6876):99-103
J:200299 Goardon N, et al., ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. EMBO J. 2006 Jan 25;25(2):357-66
J:229373 Storbeck CJ, et al., The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. Mol Biol Cell. 2009 Oct;20(19):4174-82
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:328860 Lee S, et al., A regulatory network to segregate the identity of neuronal subtypes. Dev Cell. 2008 Jun;14(6):877-89