Sequence Detail

ID/Version

P70658 P70233 O09062 P70346 O09059 Q4KMW1 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=C-X-C chemokine receptor type 4; Short=CXC-R4; Short=CXCR-4;AltName: Full=Fusin {ECO:0000303|PubMed:8955194};AltName: Full=Leukocyte-derived seven transmembrane domain receptor; Short=LESTR {ECO:0000303|PubMed:9295051

Provider

SWISS-PROT

Sequence

Polypeptide 359 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cxcr4	C-X-C motif chemokine receptor 4	120	156	4	28

Sequence references in MGI

J:37159 Heesen M, et al., Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor. J Immunol. 1996 Dec 15;157(12):5455-60
J:37252 Nagasawa T, et al., Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14726-9
J:39475 Heesen M, et al., Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms. J Immunol. 1997 Apr 15;158(8):3561-4
J:42097 Moepps B, et al., Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo. Eur J Immunol. 1997 Aug;27(8):2102-12
J:49070 Ma Q, et al., Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9448-53
J:52176 Frodl R, et al., Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues. J Recept Signal Transduct Res. 1998 Jul-Nov;18(4-6):321-44
J:57676 McGrath KE, et al., Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol. 1999 Sep 15;213(2):442-56
J:69255 Zou YR, et al., Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998 Jun 11;393(6685):595-9
J:69256 Tachibana K, et al., The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998 Jun 11;393(6685):591-4
J:135334 Bae GU, et al., Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164. J Biol Chem. 2008 Mar 28;283(13):8301-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89