Sequence Detail

ID/Version

P70451 Q61561 Q80UI3 Q6PEE5 Q8C481 Q9EQ77 (UniProt | EBI)

Last sequence update: 2006-11-28
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tyrosine-protein kinase Fer; EC=2.7.10.2;AltName: Full=Proto-oncogene c-Fer;AltName: Full=p94-Fer;

Provider

SWISS-PROT

Sequence

Polypeptide 823 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fer	FER tyrosine kinase	133	97	3	14

Sequence references in MGI

J:10171 Fischman K, et al., A murine fer testis-specific transcript (ferT) encodes a truncated Fer protein. Mol Cell Biol. 1990 Jan;10(1):146-53
J:53038 Ben-Dor I, et al., Cell cycle-dependent nuclear accumulation of the p94fer tyrosine kinase is regulated by its NH2 terminus and is affected by kinase domain integrity and ATP binding. Cell Growth Differ. 1999 Feb;10(2):113-29
J:66245 Iwanishi M, et al., The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase. J Biol Chem. 2000 Dec 15;275(50):38995-9000
J:67350 Craig AW, et al., Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation. Mol Cell Biol. 2001 Jan;21(2):603-13
J:76415 McCafferty DM, et al., Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin. J Immunol. 2002 May 15;168(10):4930-5
J:78852 Lunter PC, et al., Direct binding of plectin to Fer kinase and negative regulation of its catalytic activity. Biochem Biophys Res Commun. 2002 Aug 30;296(4):904-10
J:84709 Taler M, et al., Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells. Mol Endocrinol. 2003 Aug;17(8):1580-92
J:84866 Senis YA, et al., Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis. Exp Hematol. 2003 Aug;31(8):673-81
J:91009 Xu G, et al., Continuous association of cadherin with beta-catenin requires the non-receptor tyrosine-kinase Fer. J Cell Sci. 2004 Jul 1;117(Pt 15):3207-19
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107107 Sayegh TY, et al., Phosphorylation of N-cadherin-associated cortactin by Fer kinase regulates N-cadherin mobility and intercellular adhesion strength. Mol Biol Cell. 2005 Dec;16(12):5514-27
J:116450 Udell CM, et al., Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. J Biol Chem. 2006 Jul 28;281(30):20949-57
J:125059 Sangrar W, et al., Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion. Mol Cell Biol. 2007 Sep;27(17):6140-52
J:183970 Pasder O, et al., Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene. 2006 Jul 13;25(30):4194-206
J:183980 Kim L, et al., The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. Mol Cell Biol. 1995 Aug;15(8):4553-61
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89