Sequence Detail

ID/Version

P70399 A2AU89 Q68FD0 Q91YC9 Q8CI97 A2AU91 (UniProt | EBI)

Last sequence update: 2017-05-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=TP53-binding protein 1 {ECO:0000305}; Short=53BP1 {ECO:0000303|PubMed:11801725}; Short=p53-binding protein 1 {ECO:0000303|PubMed:11801725}; Short=p53BP1;

Provider

SWISS-PROT

Sequence

Polypeptide 1969 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trp53bp1	transformation related protein 53 binding protein 1	84	103	3	45

Sequence references in MGI

J:36914 Datta B, et al., p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J Biol Chem. 1996 Nov 1;271(44):27544-55
J:74292 Jullien D, et al., Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. J Cell Sci. 2002 Jan;115(Pt 1):71-9
J:82512 Ward IM, et al., p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol. 2003 Apr;23(7):2556-63
J:89802 Manis JP, et al., 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol. 2004 May;5(5):481-7
J:91130 Ward IM, et al., 53BP1 is required for class switch recombination. J Cell Biol. 2004 May 24;165(4):459-64
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:193246 Di Virgilio M, et al., Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science. 2013 Feb 8;339(6120):711-5
J:195061 Chapman JR, et al., RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol Cell. 2013 Mar 7;49(5):858-71
J:240587 Hartlerode AJ, et al., Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One. 2012;7(11):e49211
J:240590 Bunting SF, et al., 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 2010 Apr 16;141(2):243-54
J:262446 Dong J, et al., Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 2015 Sep 3;525(7567):134-139
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:293083 Li ML, et al., Phosphorylation of TIP60 Suppresses 53BP1 Localization at DNA Damage Sites. Mol Cell Biol. 2019 Jan 1;39(1)
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87