Sequence Detail

ID/Version

P70385 G3UWF9 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=17-beta-hydroxysteroid dehydrogenase type 3; Short=17-beta-HSD 3;AltName: Full=Estradiol 17-beta-dehydrogenase 2; EC=1.1.1.62 {ECO:0000250|UniProtKB:P37058};AltName: Full=Testicular 17-beta-hydroxysteroid dehydrogenase;AltNam

Provider

SWISS-PROT

Sequence

Polypeptide 305 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	28	103	3	10

Sequence references in MGI

J:40790 Sha JA, et al., Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA and tissue distribution of the type 1 and type 3 isoform mRNAs. J Steroid Biochem Mol Biol. 1997 Jan;60(1-2):19-24
J:301756 Sipila P, et al., The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency. FASEB J. 2020 May;34(5):6111-6128
J:302854 Rebourcet D, et al., Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production. FASEB J. 2020 Aug;34(8):10373-10386