Sequence Detail

ID/Version

P70380 (UniProt | EBI)

Last sequence update: 1998-07-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-18; Short=IL-18;AltName: Full=Interferon gamma-inducing factor; Short=IFN-gamma-inducing factor;AltName: Full=Interleukin-1 gamma; Short=IL-1 gamma;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 192 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il18	interleukin 18	119	103	2	16

Sequence references in MGI

J:35492 Okamura H, et al., Cloning of a new cytokine that induces IFN-gamma production by T cells [see comments]. Nature. 1995 Nov 2;378(6552):88-91
J:39095 Rothe H, et al., Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J Clin Invest. 1997 Feb 1;99(3):469-74
J:227990 Nowarski R, et al., Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell. 2015 Dec 3;163(6):1444-56
J:227991 Levy M, et al., Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell. 2015 Dec 3;163(6):1428-43
J:267416 Hara H, et al., The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018 Oct 26;
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89