Sequence Detail

ID/Version

P70343 C6L648 Q6P8H1 O08735 Q3TAF3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Caspase-4 {ECO:0000305}; Short=CASP-4; EC=3.4.22.64 {ECO:0000269|PubMed:30135078};AltName: Full=Caspase-11 {ECO:0000303|Ref.3}; Short=CASP-11 {ECO:0000303|Ref.3};AltName: Full=Protease ICH-3 {ECO:0000303|PubMed:870280

Provider

SWISS-PROT

Sequence

Polypeptide 373 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casp4	caspase 4, apoptosis-related cysteine peptidase	92	108	7	16

Sequence references in MGI

J:34885 Wang S, et al., Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem. 1996 Aug 23;271(34):20580-7
J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131780 Endo M, et al., C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. J Immunol. 2006 May 15;176(10):6245-53
J:193387 Aachoui Y, et al., Caspase-11 protects against bacteria that escape the vacuole. Science. 2013 Feb 22;339(6122):975-8
J:193522 Kayagaki N, et al., Non-canonical inflammasome activation targets caspase-11. Nature. 2011 Nov 3;479(7371):117-21
J:201075 Kayagaki N, et al., Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science. 2013 Sep 13;341(6151):1246-9
J:201144 Hagar JA, et al., Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science. 2013 Sep 13;341(6151):1250-3
J:226780 Kayagaki N, et al., Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015 Oct 29;526(7575):666-71
J:226781 Shi J, et al., Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015 Oct 29;526(7575):660-5
J:232572 Zanoni I, et al., An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016 Jun 3;352(6290):1232-6
J:233045 Ruhl S, et al., Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux. Eur J Immunol. 2015 Oct;45(10):2927-36
J:243015 Aachoui Y, et al., Canonical Inflammasomes Drive IFN-gamma to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe. 2015 Sep 09;18(3):320-32
J:243901 Wang Y, et al., Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Immunity. 2017 Mar 21;46(3):393-404
J:244803 Knodler LA, et al., Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host Microbe. 2014 Aug 13;16(2):249-256
J:260737 Chu LH, et al., The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018 Mar 8;9(1):996
J:265832 Lee BL, et al., Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation. J Exp Med. 2018 Sep 3;215(9):2279-2288
J:267416 Hara H, et al., The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018 Oct 26;
J:273511 Choi YJ, et al., SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol. 2019 Mar;20(3):276-287
J:296118 Wang K, et al., Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell. 2020 Mar 5;180(5):941-955.e20
J:319864 Li Z, et al., Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11. Nature. 2021 Nov;599(7884):290-295
J:332656 Shi J, et al., Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014 Oct 9;514(7521):187-92
J:332990 Broz P, et al., Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature. 2012 Oct 11;490(7419):288-91
J:333171 Cerqueira DM, et al., Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection. PLoS Pathog. 2018 Dec;14(12):e1007519
J:334741 Zhu F, et al., The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023 Apr 11;56(4):753-767.e8
J:352411 Wei C, et al., Brain endothelial GSDMD activation mediates inflammatory BBB breakdown. Nature. 2024 May;629(8013):893-900