Sequence Detail

ID/Version

P70336 A5XDA7 Q8CBR0 Q8BR64 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Rho-associated protein kinase 2; EC=2.7.11.1;AltName: Full=Rho-associated, coiled-coil-containing protein kinase 2;AltName: Full=Rho-associated, coiled-coil-containing protein kinase II; Short=ROCK-II;AltName: Full=p164 ROCK-

Provider

SWISS-PROT

Sequence

Polypeptide 1388 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rock2	Rho-associated coiled-coil containing protein kinase 2	127	118	4	25

Sequence references in MGI

J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
J:84386 Thumkeo D, et al., Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol. 2003 Jul;23(14):5043-55
J:96054 Sebbagh M, et al., Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. J Exp Med. 2005 Feb 7;201(3):465-71
J:98250 Shimizu Y, et al., ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol. 2005 Mar 14;168(6):941-53
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:125029 Pelosi M, et al., ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program. Mol Cell Biol. 2007 Sep;27(17):6163-76
J:165281 Biswas PS, et al., Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest. 2010 Sep 1;120(9):3280-95
J:209475 Saito T, et al., Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation. 2013 Jan 1;127(1):104-14
J:225274 Zhou Z, et al., A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. Neuropharmacology. 2009 Jan;56(1):81-9
J:243147 Harris SL, et al., Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice. Neuroscience. 2017 Mar 06;344:380-393
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89