Sequence Detail

ID/Version

P70288 B2RRP3 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone deacetylase 2 {ECO:0000305}; Short=HD2; EC=3.5.1.98 {ECO:0000269|PubMed:18754010, ECO:0000305|PubMed:30279482};AltName: Full=Protein deacylase HDAC2 {ECO:0000305}; EC=3.5.1.- {ECO:0000269|PubMed:30279482};AltN

Provider

SWISS-PROT

Sequence

Polypeptide 488 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hdac2	histone deacetylase 2	168	146	2	30

Sequence references in MGI

J:36570 Yang WM, et al., Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50
J:66985 Laherty CD, et al., SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell. 1998 Jul;2(1):33-42
J:82069 Yang L, et al., An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem J. 2003 Feb 1;369(Pt 3):651-7
J:106935 Davis CA, et al., PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 2006 Apr;26(7):2626-36
J:114014 Vaute O, et al., Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res. 2002 Jan 15;30(2):475-81
J:123470 Manavathi B, et al., Repression of Six3 by a corepressor regulates rhodopsin expression. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13128-33
J:140120 Nott A, et al., S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nature. 2008 Sep 18;455(7211):411-5
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:161081 Li DQ, et al., Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J Biol Chem. 2010 Mar 26;285(13):10044-52
J:168151 Kornberg MD, et al., GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol. 2010 Nov;12(11):1094-100
J:175166 Saleque S, et al., Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007 Aug 17;27(4):562-72
J:203400 He Z, et al., A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. J Biol Chem. 2011 Mar 4;286(9):7279-89
J:205031 Huang GJ, et al., ZFP932 suppresses cellular Hedgehog response and Patched1 transcription. Vitam Horm. 2012;88:309-32
J:206319 Welcker JE, et al., Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
J:209491 Naruse Y, et al., Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol Cell Biol. 2004 Jul;24(14):6278-87
J:212796 Pakala SB, et al., Regulation of NF-kappaB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis. J Biol Chem. 2010 Jul 30;285(31):23590-7
J:240892 Nitarska J, et al., A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Cell Rep. 2016 Nov 01;17(6):1683-1698
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:307864 Horisawa-Takada Y, et al., Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Nat Commun. 2021 Jun 1;12(1):3184
J:319940 Yan L, et al., PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex. Adv Sci (Weinh). 2021 Aug;8(16):e2102060
J:319948 Kelly RDW, et al., Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. Sci Rep. 2018 Oct 2;8(1):14690
J:338159 Li Y, et al., The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis. J Genet Genomics. 2022 Nov;49(11):1029-1041