Sequence Detail

ID/Version

P70278 Q496Q5 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Stimulated by retinoic acid gene 8 protein {ECO:0000303|PubMed:8896602};

Provider

SWISS-PROT

Sequence

Polypeptide 393 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Stra8	stimulated by retinoic acid gene 8	20	147	2	27

Sequence references in MGI

J:36069 Oulad-Abdelghani M, et al., Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. J Cell Biol. 1996 Oct;135(2):469-77
J:86170 Menke DB, et al., Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave. Dev Biol. 2003 Oct 15;262(2):303-12
J:107319 Koubova J, et al., Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2474-9
J:116498 Baltus AE, et al., In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. Nat Genet. 2006 Dec;38(12):1430-1434
J:139646 Mark M, et al., STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation. J Cell Sci. 2008 Oct 1;121(Pt 19):3233-42
J:142748 Anderson EL, et al., Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14976-80
J:158227 Tedesco M, et al., STRA8 shuttles between nucleus and cytoplasm and displays transcriptional activity. J Biol Chem. 2009 Dec 18;284(51):35781-93
J:166057 Matson CK, et al., The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells. Dev Cell. 2010 Oct 19;19(4):612-24
J:209945 Zhou Q, et al., Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes. Biol Reprod. 2008 Jul;79(1):35-42
J:221418 Endo T, et al., Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis. Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2347-56
J:285778 Nagaoka SI, et al., ZGLP1 is a determinant for the oogenic fate in mice. Science. 2020 Mar 6;367(6482)
J:290712 Ishiguro KI, et al., MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. Dev Cell. 2020 Feb 24;52(4):429-445.e10